Consequences of Other Medicines on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (key route) and CYP2C9 (insignificant route). For that reason, inhibitors of such isoenzymes may well reduce sildenafil clearance and inducers of those isoenzymes may perhaps raise sildenafil clearance.Usually do not share sildenafil with Others, even